TargetMol

Tilisolol HCl

Product Code:
 
TAR-T28977
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28977-5mg5mg£850.00
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TAR-T28977-50mg50mg£1,661.00
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Quantity:
TAR-T28977-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Tilisolol is a nonselective blocker of beta-adrenergic. Tilisolol hydrochloride dilates coronary arteries through an ATP-sensitive K(+)-channel opening mechanism in dogs.
CAS:
62774-96-3
Formula:
C17H25ClN2O3
Molecular Weight:
340.85
Purity:
0.98
SMILES:
Cl.Cn1cc(OCC(O)CNC(C)(C)C)c2ccccc2c1=O

References

1. Kawakami S, Ohshima N, Hirayama R, Al MH, Kitahara T, Sakaeda T, Mukai T, Nishida K, Nakamura J, Nakashima M, Sasaki H. Biodistribution and pharmacokinetics of O-palmitoyl tilisolol, a lipophilic prodrug of tilisolol, after intravenous administration in rats. Biol Pharm Bull. 2002 Aug;25(8):1072-6. PubMed PMID: 12186412. 2. Sakanaka K, Kawazu K, Nishida K, Nakamura J, Nakashima M, Nakamura T, Oshita A, Ichikawa N, Sasaki H. Transport of timolol and tilisolol in rabbit corneal epithelium. Biol Pharm Bull. 2006 Oct;29(10):2143-7. PubMed PMID: 17015968. 3. Sasaki H, Ichikawa M, Kawakami S, Yamamura K, Nishida K, Nakamura J. In situ ocular absorption of tilisolol through ocular membranes in albino rabbits. J Pharm Sci. 1996 Sep;85(9):940-3. PubMed PMID: 8877883. 4. Hayase N, Chiba K, Abiko Y, Ichihara K. Effects of tilisolol on ischemic myocardial metabolism in dogs. Eur J Pharmacol. 1994 Aug 1;260(2-3):183-90. PubMed PMID: 7988643.