TargetMol

Tocladesine

Product Code:
 
TAR-T28990
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28990-5mg5mg£850.00
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Further Information

Bioactivity:
Tocladesine, a cyclic adenosine monophosphate (cAMP) receptor agonist, is used potentially for the treatment of colorectal cancer.
CAS:
41941-56-4
Formula:
C10H11ClN5O6P
Molecular Weight:
363.65
Purity:
0.98
SMILES:
Nc1ncnc2n([C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O)c(Cl)nc12

References

1. Choi KY, Cho YJ, Kim JS, Ahn YH, Hong SH. SHC1 sensitizes cancer cells to the 8-Cl-cAMP treatment. Biochem Biophys Res Commun. 2015 Aug 7;463(4):673-8. doi: 10.1016/j.bbrc.2015.05.123. PubMed PMID: 26043699. 2. Choi KY, Ahn YH, Ahn HW, Cho YJ, Hong SH. Involvement of Akt2/protein kinase B ? (PKB?) in the 8-Cl-cAMP-induced cancer cell growth inhibition. J Cell Physiol. 2013 Apr;228(4):890-902. doi: 10.1002/jcp.24240. PubMed PMID: 23018889. 3. Bajic V, Stanimirovic Z, Stevanovic J, Spremo-Potparevic B, Zivkovic L, Milicevic Z. Cytogenetic effects of 8-Cl-cAMP on human and animal chromosomes. J BUON. 2009 Jan-Mar;14(1):71-7. PubMed PMID: 19373950. 4. Han JH, Ahn YH, Choi KY, Hong SH. Involvement of AMP-activated protein kinase and p38 mitogen-activated protein kinase in 8-Cl-cAMP-induced growth inhibition. J Cell Physiol. 2009 Jan;218(1):104-12. doi: 10.1002/jcp.21573. PubMed PMID: 18756496.