TargetMol

HE 3286

Product Code:
 
TAR-T29013
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29013-5mg5mg£270.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T29013-50mg50mg£1,026.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T29013-100mg100mg£1,564.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Triolex, an NF-kB inhibitor, is used potentially for the treatment of rheumatoid arthritis, ulcerative colitis.
CAS:
1001100-69-1
Formula:
C21H30O3
Molecular Weight:
330.468
Purity:
0.98
SMILES:
[H][C@@]12CC[C@](O)(C#C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@@H](O)C=C2C[C@@H](O)CC[C@]12C

References

1. Khan RS, Dine K, Luna E, Ahlem C, Shindler KS. HE3286 reduces axonal loss and preserves retinal ganglion cell function in experimental optic neuritis. Invest Ophthalmol Vis Sci. 2014 Aug 19;55(9):5744-51. doi: 10.1167/iovs.14-14672. PubMed PMID: 25139738; PubMed Central PMCID: PMC4161484. 2. Reading CL, Stickney DR, Flores-Riveros J, Destiche DA, Ahlem CN, Cefalu WT, Frincke JM. A synthetic anti-inflammatory sterol improves insulin sensitivity in insulin-resistant obese impaired glucose tolerance subjects. Obesity (Silver Spring). 2013 Sep;21(9):E343-9. doi: 10.1002/oby.20207. PubMed PMID: 23670958. 3. Reading CL, Frincke JM, White SK. Molecular targets for 17?-ethynyl-5-androstene-3?,7?,17?-triol, an anti-inflammatory agent derived from the human metabolome. PLoS One. 2012;7(2):e32147. doi: 10.1371/journal.pone.0032147. PubMed PMID: 22384159; PubMed Central PMCID: PMC3286445. 4. Lu M, Patsouris D, Li P, Flores-Riveros J, Frincke JM, Watkins S, Schenk S, Olefsky JM. A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab. 2010 May;298(5):E1036-48. doi: 10.1152/ajpendo.00668.2009. PubMed PMID: 20159859; PubMed Central PMCID: PMC2867370.