TargetMol

VU0400195

Product Code:
 
TAR-T29129
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29129-5mg5mg£850.00
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Quantity:
TAR-T29129-50mg50mg£1,661.00
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Quantity:
TAR-T29129-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
VU0400195 is a oral effective, positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)).
CAS:
1309434-83-0
Formula:
C21H16ClN3O3
Molecular Weight:
393.83
Purity:
0.98
SMILES:
[H][C@@]12C[C@@]([H])(C=C1)[C@]1([H])C2C(=O)N(C1=O)c1ccc(NC(=O)c2ccccn2)cc1Cl

References

1. Jones CK, Engers DW, Thompson AD, et al. Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model. J Med Chem. 2011 Nov 10;54(21):7639-47. doi: 10.1021/jm200956q. Epub 2011 Oct 19. PubMed PMID: 21966889; PubMed Central PMCID: PMC3226828.