TargetMol

WB403

Product Code:
 
TAR-T29154
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29154-5mg5mg£850.00
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Quantity:
TAR-T29154-50mg50mg£1,661.00
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Quantity:
TAR-T29154-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
WB403 is a TGR5 activator. WB403 significantly decreases fasting blood glucose, postprandial blood glucose and HbA1c, improves glucose tolerance in type 2 diabetic mice. WB403 increases pancreatic β-cells and restores the normal distribution pattern of α-cell and β-cell in islets.
CAS:
1594041-84-5
Formula:
C19H19BrN2OS
Molecular Weight:
403.34
Purity:
0.98
SMILES:
CCc1cc(ccn1)-c1nc(C)c(COCc2ccc(Br)cc2)s1

References

1. Zheng C, Zhou W, Wang T, You P, Zhao Y, Yang Y, Wang X, Luo J, Chen Y, Liu M, Chen H. A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic ?-Cells in Type 2 Diabetic Mice. PLoS One. 2015 Jul 24;10(7):e0134051. doi: 10.1371/journal.pone.0134051. eCollection 2015. PubMed PMID: 26208278; PubMed Central PMCID: PMC4514850.