TargetMol

Acetylaminofluorene-dG

Product Code:
 
TAR-T29596
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29596-5mg5mg£850.00
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Quantity:
TAR-T29596-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T29596-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Acetylaminofluorene-dG is a carcinogenic adduct which covalently binds DNA bases and promotes mutagenesis near the adduct site.
CAS:
37819-60-6
Formula:
C25H24N6O5
Molecular Weight:
488.504
Purity:
0.98
SMILES:
CC(=O)N(c1nc2c(nc(N)[nH]c2=O)n1[C@H]1C[C@H](O)[C@@H](CO)O1)c1ccc-2c(Cc3ccccc-23)c1

References

1. Xu L, Cho BP. Conformational Insights into the Mechanism of Acetylaminofluorene-dG-Induced Frameshift Mutations in the NarI Mutational Hotspot. Chem Res Toxicol. 2016 Feb 15;29(2):213-26. doi: 10.1021/acs.chemrestox.5b00484. Epub 2016 Jan 15. PubMed PMID: 26733364. 2. Schorr S, Carell T. Mechanism of acetylaminofluorene-dG induced frameshifting by polymerase ?. Chembiochem. 2010 Dec 10;11(18):2534-7. doi: 10.1002/cbic.201000579. PubMed PMID: 21064171. 3. Guo D, Xie Z, Shen H, Zhao B, Wang Z. Translesion synthesis of acetylaminofluorene-dG adducts by DNA polymerase zeta is stimulated by yeast Rev1 protein. Nucleic Acids Res. 2004 Feb 11;32(3):1122-30. Print 2004. PubMed PMID: 14960722; PubMed Central PMCID: PMC373411.