TargetMol

Deferitazole

Product Code:
 
TAR-T31362
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T31362-1mg1mg£175.00
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TAR-T31362-5mg5mg£328.00
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TAR-T31362-10mg10mg£456.00
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TAR-T31362-25mg25mg£702.00
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TAR-T31362-50mg50mg£938.00
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Further Information

Bioactivity:
Deferitazole(FBS-0701, SPD-602) is a new orally active Antimalarial iron chelator for the treatment of transfusional iron overload. In addition, Deferitazole blocks transmission by Plasmodium falciparum gametocyte.
CAS:
945635-15-4
Formula:
C18H25NO7S
Molecular Weight:
399.46
Purity:
0.98
SMILES:
COCCOCCOCCOc1cccc(C2=N[C@](C)(CS2)C(O)=O)c1O

References

1. Hider RC, Kong X, Abbate V, Harland R, Conlon K, Luker T. Deferitazole, a new orally active iron chelator. Dalton Trans. 2015 Mar 21;44(11):5197-204. doi: 10.1039/c5dt00063g. PubMed PMID: 25687725. 2. Ferrer P, Vega-Rodriguez J, Tripathi AK, Jacobs-Lorena M, Sullivan DJ Jr. Antimalarial iron chelator FBS0701 blocks transmission by Plasmodium falciparum gametocyte activation inhibition. Antimicrob Agents Chemother. 2015 Mar;59(3):1418-26. doi: 10.1128/AAC.04642-14. Epub 2014 Dec 15. PubMed PMID: 25512427; PubMed Central PMCID: PMC4325789. 3. Gumienna-Kontecka E, Pyrkosz-Bulska M, Szebesczyk A, Ostrowska M. Iron chelating strategies in systemic metal overload, neurodegeneration and cancer. Curr Med Chem. 2014;21(33):3741-67. Review. PubMed PMID: 25005181. 4. Ferrer P, Tripathi AK, Clark MA, Hand CC, Rienhoff HY Jr, Sullivan DJ Jr. Antimalarial iron chelator, FBS0701, shows asexual and gametocyte Plasmodium falciparum activity and single oral dose cure in a murine malaria model. PLoS One. 2012;7(5):e37171. doi: 10.1371/journal.pone.0037171. Epub 2012 May 21. PubMed PMID: 22629364; PubMed Central PMCID: PMC3357340.