TargetMol

MW01-2-151SRM

Product Code:
 
TAR-T33535
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T33535-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T33535-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T33535-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
MW01-2-151SRM is A CNS penetrant that acts as A selective inhibitor of β amyloid A. MW01-2-151SRM selectively restores injury - or disease-induced proinflammatory cytokine overproduction to maintain homeostasis.
CAS:
886208-65-7
Formula:
C19H20N6
Molecular Weight:
332.411
Purity:
0.98
SMILES:
Cc1cc(nnc1N1CCN(CC1)c1ncccn1)-c1ccccc1

References

Macauley SL, Wong AM, Shyng C, Augner DP, Dearborn JT, Pearse Y, Roberts MS, Fowler SC, Cooper JD, Watterson DM, Sands MS. An anti-neuroinflammatory that targets dysregulated glia enhances the efficacy of CNS-directed gene therapy in murine infantile neuronal ceroid lipofuscinosis. J Neurosci. 2014 Sep 24;34(39):13077-82. doi: 10.1523/JNEUROSCI.2518-14.2014. PubMed PMID: 25253854; PubMed Central PMCID: PMC4172802. Jenrow KA, Brown SL, Kolozsvary AJ, Lapanowski K, Kim JH. Time-dependent inhibition of pan-inflammatory cytokines mitigates radiation-induced skin injury in mice. Radiat Res. 2014 Sep;182(3):316-21. doi: 10.1667/RR13711.1. Epub 2014 Aug 6. PubMed PMID: 25098729. Webster SJ, Van Eldik LJ, Watterson DM, Bachstetter AD. Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment. J Neurosci. 2015 Apr 22;35(16):6554-69. doi: 10.1523/JNEUROSCI.0291-15.2015. PubMed PMID: 25904805; PubMed Central PMCID: PMC4405562. Bachstetter AD, Webster SJ, Goulding DS, Morton JE, Watterson DM, Van Eldik LJ. Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic. J Neuroinflammation. 2015 Apr 10;12:69. doi: 10.1186/s12974-015-0289-5. PubMed PMID: 25886256; PubMed Central PMCID: PMC4396836.