TargetMol

Naxifylline

Product Code:
 
TAR-T33600
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T33600-5mg5mg£1,155.00
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Quantity:
TAR-T33600-50mg50mg£2,464.00
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Quantity:
TAR-T33600-100mg100mg£3,283.00
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This product comes from: United States.
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Further Information

Bioactivity:
Naxifylline is an A1 adenosine receptor antagonist that promotes urine volume to prevent the decline in renal function observed during diuretic therapy for the treatment of edema associated with congestive heart failure.
CAS:
166374-49-8
Formula:
C18H24N4O3
Molecular Weight:
344.415
Purity:
0.98
SMILES:
[H][C@]12O[C@]1([H])[C@]1([H])C[C@@]2([H])C[C@H]1c1nc2n(CCC)c(=O)n(CCC)c(=O)c2[nH]1

References

Gottlieb SS, Brater DC, Thomas I, Havranek E, Bourge R, Goldman S, Dyer F, Gomez M, Bennett D, Ticho B, Beckman E, Abraham WT. BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy. Circulation. 2002 Mar 19;105(11):1348-53. Erratum in: Circulation 2002 Sep 24;106(13):1743. PubMed PMID: 11901047. Gottlieb SS, Skettino SL, Wolff A, Beckman E, Fisher ML, Freudenberger R, Gladwell T, Marshall J, Cines M, Bennett D, Liittschwager EB. Effects of BG9719 (CVT-124), an A1-adenosine receptor antagonist, and furosemide on glomerular filtration rate and natriuresis in patients with congestive heart failure. J Am Coll Cardiol. 2000 Jan;35(1):56-9. PubMed PMID: 10636259.