TargetMol

TAK-044

Product Code:
 
TAR-T34773
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T34773-5mg5mg£850.00
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Further Information

Bioactivity:
TAK-044 is an endotheliin receptor antagonist that prevents and reverses the development of carbon tetrachloride induced cirrhosis in rats. TAK-044 showed a protective effect on neuronal activity in vitro hypoxic glucose deprivation model of stroke.
CAS:
157380-72-8
Formula:
C45H51N9Na2O11S
Molecular Weight:
971.99
Purity:
0.98
SMILES:
[Na+].[Na+].CC(C)CC1NC(=O)C(NC(=O)C(CC([O-])=O)NC(=O)C(CC(=O)N2CCN(CC2)c2ccccc2)NC(=O)C(CC([O-])=O)NC(=O)C(Cc2c[nH]c3ccccc23)NC1=O)c1cccs1

References

Briyal S, Pant AB, Gupta YK. Protective effect of endothelin antagonist (TAK-044) on neuronal cell viability in in vitro oxygen-glucose deprivation model of stroke. Indian J Physiol Pharmacol. 2006 Apr-Jun;50(2):157-62. PubMed PMID: 17051735. Behrend M. The endothelin receptor antagonist TAK-044 in the treatment of reperfusion injury in organ transplantation. Expert Opin Investig Drugs. 1999 Jul;8(7):1079-91. PubMed PMID: 15992108. Briyal S, Gulati A, Gupta YK. Effect of combination of endothelin receptor antagonist (TAK-044) and aspirin in middle cerebral artery occlusion model of acute ischemic stroke in rats. Methods Find Exp Clin Pharmacol. 2007 May;29(4):257-63. PubMed PMID: 17609737. Gupta YK, Briyal S, Sharma U, Jagannathan NR, Gulati A. Effect of endothelin antagonist (TAK-044) on cerebral ischemic volume, oxidative stress markers and neurobehavioral parameters in the middle cerebral artery occlusion model of stroke in rats. Life Sci. 2005 May 20;77(1):15-27. PubMed PMID: 15848215.