TargetMol

Neoaureothin

Product Code:
 
TAR-T35668
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35668-5mg5mg£2,522.00
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This product comes from: United States.
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Further Information

Bioactivity:
Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC50 = 13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50 = 1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC50s = 34.3, 47, and 37.2 μg/ml, respectively). It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50 = 0.84 μg/ml) and increases survival of P. densiflora trees inoculated with B. xylophilus.
CAS:
59795-94-7
Formula:
C28H31NO6
Molecular Weight:
477.6
Purity:
0.98
SMILES:
CC(/C=C1CO[C@@H](C(OC(OC)=C2C)=C(C)C2=O)C1)=CC(C)=CC(C)=CC3=CC=C([N+]([O-])=O)C=C3