TargetMol

Nemadipine-A

Product Code:
 
TAR-T35729
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35729-5mg5mg£850.00
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Quantity:
TAR-T35729-50mg50mg£1,661.00
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Quantity:
TAR-T35729-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.
CAS:
54280-71-6
Formula:
C19H18F5NO4
Molecular Weight:
419.348
Purity:
0.98
SMILES:
CCOC(=O)C1=C(C)NC(C)=C(C1c1c(F)c(F)c(F)c(F)c1F)C(=O)OCC