TargetMol

TCS-PIM-1-4a

Product Code:
 
TAR-T4215
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4215-5mg5mg£108.00
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Quantity:
TAR-T4215-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T4215-10mg10mg£127.00
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TAR-T4215-25mg25mg£172.00
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TAR-T4215-50mg50mg£252.00
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Quantity:
TAR-T4215-100mg100mg£343.00
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This product comes from: United States.
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Further Information

Bioactivity:
TCS-PIM-1-4a, a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).
CAS:
327033-36-3
Formula:
C11H6F3NO2S
Molecular Weight:
273.23
Pathway:
Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling
Purity:
0.9989
SMILES:
FC(F)(F)c1cccc(C=C2SC(=O)NC2=O)c1
Target:
Apoptosis; Pim

References

Xia Z, et al. Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases. J. Med. Chem., 2009, 52 (1), pp 74-86 Beharry Z, et al. The Pim protein kinases regulate energy metabolism and cell growth. Proc Natl Acad Sci U S A. 2011;108(2):528-33. Benoit SR, Ji M, Fleming R,et al . Predictors of dropouts from a San Diego diabetes program: a case control study. Prev Chronic Dis. 2004:1(4):A10. Lin YW, et al. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 ;115(4):824-33.