TargetMol

(-)-(S)-Equol

Product Code:
 
TAR-T6491
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6491-5mg5mg£105.00
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Quantity:
TAR-T6491-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T6491-10mg10mg£119.00
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TAR-T6491-25mg25mg£152.00
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TAR-T6491-50mg50mg£209.00
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TAR-T6491-100mg100mg£314.00
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Quantity:
TAR-T6491-500mg500mg£667.00
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This product comes from: United States.
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Further Information

Bioactivity:
S-equol is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective and estrogen receptor (ER) modulating activities. S-equol preferentially binds to and activates the beta isoform of ER in certain target tissues, while having an antagonistic effect in other tissues. This modulates the expression of ER-responsive genes in a tissue-specific manner. This agent may increase bone mineral density, affect vasomotor symptoms, and may decrease the proliferation rate of susceptible cancer cells. In addition, this agent interferes with the activity of enzymes involved in steroid biosynthesis. S-equol inhibits dihydrotestosterone (DHT) production and may inhibit the proliferation of androgen-driven prostate cancer. S-equol is the biologically active enantiomer while R-equol is essentially inactive and has a weak affinity for alpha-ER.
CAS:
531-95-3
Formula:
C15H14O3
Molecular Weight:
242.274
Pathway:
Endocrinology/Hormones; Metabolism
Purity:
0.9961
SMILES:
Oc1ccc(cc1)[C@H]1COc2cc(O)ccc2C1
Target:
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite

References

Muthyala RS, et al. Bioorg Med Chem, 2004, 12(6), 1559-1567. Sathyamoorthy N, et al. Eur J Cancer, 1997, 33(14), 2384-2389. Setchell KD, et al. J Nutr, 2002, 132(12), 3577-3584. Adlercreutz H, et al. Lancet, 1982, 2(8311), 1295-1299.