TargetMol

Sophocarpine

Product Code:
 
TAR-T6677
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6677-5mg5mg£107.00
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TAR-T6677-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T6677-10mg10mg£128.00
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TAR-T6677-25mg25mg£187.00
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TAR-T6677-50mg50mg£243.00
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TAR-T6677-100mg100mg£329.00
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This product comes from: United States.
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Further Information

Bioactivity:
Sophocarpine has anti-cancer, anti-inflammatory, anti-nociceptive, and antivirus activities, it can prevent implant loosening through inhibiting osteoclast formation and bone resorption, thus, it may be a novel therapeutic agent to prevent prosthesis loosening and for osteolytic diseases. Sophocarpine could attenuate ConA-induced liver injury, and the protective effect of Sophocarpine was associated with its inhibition effect of pro-inflammatory cytokines, chemokines, and the IFN-γ/STAT1 signaling pathway.
CAS:
6483-15-4
Formula:
C15H22N2O
Molecular Weight:
246.35
Pathway:
NF-κb; Stem Cells; Neuroscience; MAPK; Tyrosine Kinase/Adaptors; Immunology/Inflammation; Angiogenesis; JAK/STAT signaling
Purity:
0.9867
SMILES:
O=C(C=CC1)N(C[C@@H]2CCC3)[C@H]1[C@@H]1[C@H]2N3CCC1
Target:
ERK; p38 MAPK; NF-κB; TLR; COX; HER; JNK; STAT

References

Song CY, et al. Sophocarpine alleviates hepatocyte steatosis through activating AMPK signaling pathway. Toxicol In Vitro. 2013 Apr;27(3):1065-71. Liu XQ, et al. [Thymopolypeptides combined with matrine type alkaloids suppress HBV replication]. Zhongguo Zhong Yao Za Zhi. 2016 Apr;41(7):1275-1281. Chinese. Gao Y, et al. Anti-inflammatory effects of sophocarpine in LPS-induced RAW 264.7 cells via NF-?B and MAPKs signaling pathways. Toxicol In Vitro. 2012 Feb;26(1):1-6. Zhang Y, et al. Sophocarpine and matrine inhibit the production of TNF-alpha and IL-6 in murine macrophages and prevent cachexia-related symptoms induced by colon26 adenocarcinoma in mice. Int Immunopharmacol. 2008 Dec 20;8(13-14):1767-72.