TargetMol

Licochalcone C

Product Code:
 
TAR-T7028
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T7028-50mg50mgEnquire
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TAR-T7028-1mg1mg£197.00
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TAR-T7028-1mL1 mL * 10 mM (in DMSO)£306.00
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TAR-T7028-5mg5mg£389.00
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TAR-T7028-10mg10mg£544.00
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TAR-T7028-25mg25mg£830.00
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Further Information

Bioactivity:
Licochalcone C has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, anti-inflammatory, and anti-apoptotic activities. Licochalcone C exhibit inhibitory activity with cytotoxicity in a rat basophilic leukaemia cell line, RBL-2H3. Licochalcone C induces apoptosis via B-cell lymphoma 2 family proteins in T24 cells, it may be a potential adjuvant therapeutic agent for bladder cancer.
CAS:
144506-14-9
Formula:
C21H22O4
Molecular Weight:
338.403
Pathway:
oxidation-reduction; Metabolism
Purity:
0.9993
SMILES:
COc1c(C=CC(=O)c2ccc(O)cc2)ccc(O)c1CC=C(C)C
Target:
Phosphatase; Antioxidant; Glucosidase

References

Tanifuji S, et al. Licochalcones suppress degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells.[J]. International Immunopharmacology, 2010, 10(7):769-776. Zhou M, et al. Role of licochalcone C in cardioprotection against ischemia/reperfusion injury of isolated rat heart via antioxidant, anti-inflammatory, and anti-apoptotic activities.[J]. Life Sciences, 2015, 132:27-33. Wang P, et al. Licochalcone C induces apoptosis via B-cell lymphoma 2 family proteins in T24 cells[J]. Molecular Medicine Reports, 2015, 12(5):7623. Zhao W, Wu R. Concise synthesis of licochalcone C and its regioisomer, licochalcone H[J]. Archives of Pharmacal Research, 2013, 36(12):1432-1436.