TargetMol

SKI V

Product Code:
 
TAR-T8461
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8461-1mg1mg£148.00
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TAR-T8461-1mL1 mL * 10 mM (in DMSO)£253.00
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TAR-T8461-5mg5mg£256.00
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TAR-T8461-10mg10mg£367.00
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TAR-T8461-25mg25mg£570.00
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TAR-T8461-50mg50mg£781.00
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Quantity:
TAR-T8461-100mg100mg£1,026.00
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Further Information

Bioactivity:
SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces apoptosis and has antitumor activity
CAS:
24418-86-8
Formula:
C15H10O4
Molecular Weight:
254.241
Pathway:
GPCR/G Protein; PI3K/Akt/mTOR signaling; Apoptosis
Purity:
0.9962
SMILES:
Oc1ccc(C=C2Oc3ccccc3C2=O)cc1O
Target:
Apoptosis; PI3K; S1P Receptor

References

French KJ, et al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15;63(18):5962-9. French KJ, et al. Antitumor activity of sphingosine kinase inhibitors. J Pharmacol Exp Ther. 2006 Aug;318(2):596-603.