TargetMol

GW6471

Product Code:
 
TAR-T8486
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8486-1mg1mg£111.00
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TAR-T8486-5mg5mg£168.00
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TAR-T8486-1mL1 mL * 10 mM (in DMSO)£205.00
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TAR-T8486-10mg10mg£213.00
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TAR-T8486-25mg25mg£309.00
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TAR-T8486-50mg50mg£431.00
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TAR-T8486-100mg100mg£603.00
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TAR-T8486-500mg500mg£1,187.00
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Further Information

Bioactivity:
GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.
CAS:
880635-03-0
Formula:
C35H36F3N3O4
Molecular Weight:
619.685
Pathway:
DNA Damage/DNA Repair; Metabolism
Purity:
0.9988
SMILES:
CCC(=O)NC[C@H](Cc1ccc(OCCc2nc(oc2C)-c2ccccc2)cc1)NC(C)=C/C(=O)c1ccc(cc1)C(F)(F)F
Target:
PPAR

References

Xu HE, et al. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature. 2002 Feb 14;415(6873):813-7. Abu Aboud O, et al. PPAR? inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth. Am J Physiol Cell Physiol. 2015 Jun 1;308(11):C890-8. Abu Aboud O, et al. Inhibition of PPAR? induces cell cycle arrest and apoptosis, and synergizes with glycolysisinhibition in kidney cancer cells. PLoS One. 2013 Aug 7;8(8):e71115. Wang R, Zhao J, Jin J, et al. WY-14643 attenuates lipid deposition via activation of the PPAR?/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC. Lipids in Health and Disease. 2022, 21(1): 1-18.