TargetMol

AC1903

Product Code:
 
TAR-T8528
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8528-5mg5mg£113.00
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TAR-T8528-1mL1 mL * 10 mM (in DMSO)£118.00
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TAR-T8528-10mg10mg£144.00
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TAR-T8528-25mg25mg£230.00
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TAR-T8528-50mg50mg£347.00
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Further Information

Bioactivity:
AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.
CAS:
831234-13-0
Formula:
C19H17N3O
Molecular Weight:
303.365
Pathway:
Membrane transporter/Ion channel
Purity:
0.9833
SMILES:
C(Nc1nc2ccccc2n1Cc1ccccc1)c1ccco1
Target:
TRP/TRPV Channel

References

Yiming Zhou, et al. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science Sharma S H , Pablo J L , Montesinos M S , et al. Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903[J]. Bioorganic & Medicinal Chemistry Letters, 2018.