TargetMol

GSK620

Product Code:
 
TAR-T9020
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9020-1mg1mg£97.00
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TAR-T9020-5mg5mg£132.00
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TAR-T9020-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T9020-10mg10mg£168.00
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TAR-T9020-25mg25mg£269.00
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TAR-T9020-50mg50mg£389.00
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TAR-T9020-100mg100mg£544.00
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TAR-T9020-500mg500mg£1,099.00
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Further Information

Bioactivity:
GSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 shows an anti-inflammatory phenotype in human whole blood.
CAS:
2088410-46-0
Formula:
C18H19N3O3
Molecular Weight:
325.368
Pathway:
Chromatin/Epigenetic
Purity:
0.9988
SMILES:
CNC(=O)c1cc(cn(Cc2ccccc2)c1=O)C(=O)NC1CC1
Target:
Epigenetic Reader Domain

References

Seal JT, et al. The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor. J Med Chem. 2020;63(17):9093-9126.