TargetMol

4,5-Dimethoxycanthin-6-one

Product Code:
 
TAR-TN3013
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN3013-1mg1mg£189.00
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TAR-TN3013-1mL1 mL * 10 mM (in DMSO)£341.00
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TAR-TN3013-5mg5mg£369.00
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TAR-TN3013-10mg10mg£550.00
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TAR-TN3013-25mg25mg£821.00
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TAR-TN3013-50mg50mg£1,083.00
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Further Information

Bioactivity:
4,5-Dimethoxycanthin-6-one has antibacterial actiyity, it exhibits inhibition against Staphylococcus aureus and its drug-resistant strains. 4,5-Dimethoxycanthin-6-one has a strong inhibitory effect on cyclic adenosine monophosphate (cAMP) phosphodiesterase. It also shows cytotoxicity against the tumor cell lines, U937 and HepG2.
CAS:
18110-87-7
Formula:
C16H12N2O3
Molecular Weight:
280.3
Pathway:
GPCR/G Protein; Microbiology/Virology
Purity:
0.98
SMILES:
COc1c(OC)c(=O)n2c3ccccc3c3ccnc1c23
Target:
cAMP; Antifection

References

Miao X, et al. In vitro metabolism of 4, 5-dimethoxycanthin-6-one by human liver microsomes and its inhibition on human CYP1ALife Sci. 2017;190:46-51. Li W, et al. 4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis. Cancer Cell Int. 2022;22(1):32. OHMoTo T, et al. Studies on the constituents of Picrasma quassioides BENNET. III. The alkaloidal constituents. Chemical and pharmaceutical bulletin. 1984;32(9): 3579-3583.