TargetMol

Cintirorgon sodium

Product Code:
 
TAR-TQ0007L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0007L-5mg5mg£1,171.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-TQ0007L-50mg50mg£2,303.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-TQ0007L-100mg100mg£3,042.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Cintirorgon (LYC-55716) is an orally active RORgamma agonist with potential immunomodulatory and antineoplastic activities. LYC-55716 selectively binds to the RORg, and binds to ROR response elements, enhancing the function, proliferation, and survival of type 17 T cells, including helper T cells and cytotoxic T cells.
CAS:
2055538-47-9
Formula:
C27H22F6NNaO6S
Molecular Weight:
625.51
Purity:
0.98
SMILES:
CC(C)(C[C@H]1CN(c2cc(ccc2O1)-c1cc(F)cc(OC(F)F)c1)S(=O)(=O)c1cccc(c1)C(F)(F)F)C(=O)O[Na]

References

Mahalingam D, Wang JS, Hamilton EP, Sarantopoulos J, Nemunaitis J, Weems G, Carter L, Hu X, Schreeder M, Wilkins HJ. Phase 1 Open-Label, Multicenter Study of First-in-Class ROR? Agonist LYC-55716 (Cintirorgon): Safety, Tolerability, and Preliminary Evidence of Antitumor Activity. Clin Cancer Res. 2019 Jun 15;25(12):3508-3516. doi: 10.1158/1078-0432.CCR-18-3185. Epub 2019 Feb 28. PubMed PMID: 30819679.