TargetMol

AS19

Product Code:
 
TAR-T10380
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10380-5mg5mg£457.00
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TAR-T10380-50mg50mg£1,821.00
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Quantity:
TAR-T10380-100mg100mg£2,319.00
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This product comes from: United States.
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Further Information

Bioactivity:
AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis: 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively).
CAS:
1000578-26-6
Formula:
C18H25N3
Molecular Weight:
283.419
Pathway:
Neuroscience; GPCR/G Protein
Purity:
0.98
SMILES:
CN(C)[C@H]1CCc2c(C1)cccc2-c1c(C)nn(C)c1C
Target:
5-HT Receptor

References

1. Perez-Garc?a GS, et al. Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. Behav Brain Res. 2005 Aug 30;163(1):136-40. 2. Le?n-Ponte M, et al. Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor. Blood. 2007 Apr 15;109(8):3139-46. 3. Brenchat A, et al. 5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice. Pain. 2009 Feb;141(3):239-47.