TargetMol

Zolmitriptan

Product Code:
 
TAR-T1092
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1092-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T1092-10mg10mg£113.00
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TAR-T1092-25mg25mg£152.00
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TAR-T1092-50mg50mg£186.00
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TAR-T1092-100mg100mg£254.00
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Further Information

Bioactivity:
Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brainstem sensory nuclei. Zolmitriptan is a member of the triptan class of agents with anti-migraine properties. Receptor binding results in constriction of cranial vessels, reduction of vessel pulsation and inhibition of nociceptive transmission, thereby providing relief of migraine headaches. Zolmitriptan may also relieve migraine headaches by inhibition of pro-inflammatory neuropeptide release.
CAS:
139264-17-8
Formula:
C16H21N3O2
Molecular Weight:
287.363
Pathway:
Neuroscience; GPCR/G Protein
Purity:
0.988
SMILES:
CN(C)CCc1c[nH]c2ccc(C[C@H]3COC(=O)N3)cc12
Target:
5-HT Receptor

References

1. Martin GR, et al. Br J Pharmacol,1997, 121(2), 157-164. 2. Le Grand B, et al. Eur J Pharmacol, 2000, 397(2-3), 297-302. 3. MacLennan SJ, et al. Eur J Pharmacol,1998, 361(2-3), 191-197. 4. de Almeida RM, et al. Psychopharmacology (Berl),2001, 157(2), 131-141.