TargetMol

DI-591

Product Code:
 
TAR-T11033
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11033-5mg5mg£371.00
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Quantity:
TAR-T11033-50mg50mg£1,556.00
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Quantity:
TAR-T11033-100mg100mg£2,456.00
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This product comes from: United States.
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Further Information

Bioactivity:
DI-591 is an effective, high-affinity and cell-permeability inhibitor for DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 and nM and 10.4 nM, respectively, and has no obvious binding to DCN3, DCN4 and DCN5 proteins.
CAS:
2245887-38-9
Formula:
C31H47N5O4S
Molecular Weight:
585.81
Purity:
0.98
SMILES:
CCC(=O)N[C@@H](Cc1nc2ccc(cc2s1)C(C)C)C(=O)N[C@H](CNC(=O)CCN1CCOCC1)C1CCCCC1

References

1. Zhou H, et al. A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation. Nat Commun. 2017 Oct 27;8(1):1150.