TargetMol

H4R antagonist 1

Product Code:
 
TAR-T11532
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11532-5mg5mg£430.00
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TAR-T11532-50mg50mg£1,661.00
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TAR-T11532-100mg100mg£2,079.00
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Further Information

Bioactivity:
H4R antagonist 1 is a highly selective histamine H4 receptor (H4R) antagonist (IC50: 27 nM). H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R.
CAS:
1429375-54-1
Formula:
C11H11BrN8
Molecular Weight:
335.169
Pathway:
Neuroscience; GPCR/G Protein; Immunology/Inflammation
Purity:
0.98
SMILES:
CNC1CN(C1)c1nc2ncc(Br)cc2n2nnnc12
Target:
Histamine Receptor

References

1. Ko K, et al. Discovery of a Novel Highly Selective Histamine H4 Receptor Antagonist for the Treatment of Atopic Dermatitis. J Med Chem. 2018 Apr 12;61(7):2949-2961.