TargetMol

Vps34-IN-2

Product Code:
 
TAR-T13311
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13311-5mg5mg£462.00
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TAR-T13311-50mg50mg£1,821.00
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Quantity:
TAR-T13311-100mg100mg£2,319.00
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This product comes from: United States.
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Further Information

Bioactivity:
Vps34-IN-2 is a potent and selective Vps34 inhibitor (IC50s: 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively).
CAS:
1523404-29-6
Formula:
C18H25F3N4O3
Molecular Weight:
402.418
Pathway:
PI3K/Akt/mTOR signaling
Purity:
0.98
SMILES:
CC(C)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1CCOC[C@H]1C)C(F)(F)F
Target:
PI3K

References

1. Pasquier B, et al. Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors. J Med Chem. 2015 Jan 8;58(1):376-400.