TargetMol

S 18986

Product Code:
 
TAR-T16816
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16816-50mg50mgEnquire
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TAR-T16816-1mg1mg£106.00
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TAR-T16816-5mg5mg£148.00
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TAR-T16816-10mg10mg£209.00
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TAR-T16816-25mg25mg£360.00
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Further Information

Bioactivity:
S 18986 displays cognitive enhancing properties in rodents. S 18986 is a selective and brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests..
CAS:
175340-20-2
Formula:
C10H12N2O2S
Molecular Weight:
224.28
Pathway:
Neuroscience
Purity:
0.98
SMILES:
O=S1(=O)N[C@H]2CCCN2c2ccccc12
Target:
GluR

References

Bernard K, et al. DRUG FOCUS: S 18986: A positive allosteric modulator of AMPA-type glutamate receptorspharmacological profile of a novel cognitive enhancer. CNS Neurosci Ther. 2010 Oct;16(5):e193-212. Bourasset F, et al. Neuropharmacokinetics of a new alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat. Drug Metab Dispos. 2005 Aug;33(8):1137-43.