TargetMol

SB269652

Product Code:
 
TAR-T16857
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16857-5mg5mg£458.00
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Quantity:
TAR-T16857-50mg50mg£1,564.00
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Quantity:
TAR-T16857-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor.
CAS:
215802-15-6
Formula:
C27H30N4O
Molecular Weight:
426.564
Purity:
0.98
SMILES:
O=C(N[C@H]1CC[C@H](CCN2CCc3ccc(cc3C2)C#N)CC1)c1cc2ccccc2[nH]1

References

1. Silvano E, et al. The tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptors. Mol Pharmacol. 2010 Nov;78(5):925-34. 2. Lane JR, et al. A new mechanism of allostery in a G protein-coupled receptor dimer. Nat Chem Biol. 2014 Sep;10(9):745-52. 3. Presgraves SP, et al. Involvement of dopamine D(2)/D(3) receptors and BDNF in the neuroprotective effects of S32504 and pramipexole against 1-methyl-4-phenylpyridinium in terminally differentiated SH-SY5Y cells. Exp Neurol. 2004 Nov;190(1):157-70.