TargetMol

CAY10682

Product Code:
 
TAR-T36192
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36192-5mg5mg£850.00
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TAR-T36192-50mg50mg£1,661.00
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Quantity:
TAR-T36192-100mg100mg£2,079.00
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Further Information

Bioactivity:
(?)-Nutlin-3 blocks the interaction of p53 with its negative regulator Mdm2 (IC50 = 90 nM), inducing the expression of p53-regulated genes and blocking the growth of tumor xenografts in vivo. CAY10682 is a pyrrolo[3,4c]pyrazole derivative that inhibits the p53-Mdm2 interaction as potently as (?)-nutlin-3 (Ki = 83 nM) and also dose-dependently reduces activation of the NF-κB pathway. It specifically prevents phosphorylation of IκBα by the kinases IKKα, IKKβ, and IKK (IC50s = 80.5, 78.2, and 57.1 μM, respectively). CAY10682 blocks the growth of cancer cells in vitro (IC50s = 2-6 μM) and inhibits the growth of A549 cell xenografts in mice without significantly reducing body weight.
CAS:
1542066-74-9
Formula:
C30H25BrFN5O
Molecular Weight:
570.466
Purity:
0.98
SMILES:
Fc1ccc(Cn2nc(c3C(N(CCCn4ccnc4)C(=O)c23)c2ccc(Br)cc2)-c2ccccc2)cc1