TargetMol

Juglone

Product Code:
 
TAR-T4010
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4010-5mg5mg£103.00
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TAR-T4010-10mg10mg£115.00
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TAR-T4010-25mg25mg£148.00
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TAR-T4010-50mg50mg£179.00
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TAR-T4010-100mg100mg£222.00
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Further Information

Bioactivity:
Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.
CAS:
481-39-0
Formula:
C10H6O3
Molecular Weight:
174.155
Pathway:
DNA Damage/DNA Repair; Cell Cycle/Checkpoint; Microbiology/Virology
Purity:
0.9873
SMILES:
Oc1cccc2C(=O)C=CC(=O)c12
Target:
DNA/RNA Synthesis; Antibacterial

References

Reese S, et al. The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model. Fibrogenesis Tissue Repair. 2010 Jan 4;3:1. Hennig L, et al. Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone. Biochemistry. 1998 Apr 28;37(17):5953-60. Chao SH, et al. Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription. Nucleic Acids Res. 2001 Feb 1;29(3):767-73.