TargetMol

ShK-Dap22

Product Code:
 
TAR-TP2123
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP2123-10mg10mg£1,981.00
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Further Information

Bioactivity:
Extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Selective for KV1.3 over other mammalian potassium channels (IC50 values are 23, 1800, 10500, 37000 and 39000 pM for mKV1.3, mKV1.1, hKV1.6, mKV1.4 and rKV1.2 respectively, and >100000 pM for hKV1.5, mKV1.7, hKV3.1, rKV3.4 and hKCa4). Suppresses T cell activation in vitro (IC50 < 500 pM).
CAS:
220384-25-8
Formula:
C166H268N54O48S7
Molecular Weight:
4012.7
Purity:
0.98
SMILES:
0

References

Kalman et al (1998) ShK-Dap22, a potent KV1.3-specific immunosuppresive polypeptide. J.Biol.Chem. 273 32697 PMID: Robbins et al (2005) Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via KV1.3 channels. J.Physiol. 564 131 PMID: