TargetMol

Dihydro-β-erythroidine hydrobromide

Product Code:
 
TAR-T11041
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11041-5mg5mg£340.00
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TAR-T11041-50mg50mg£1,251.00
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Quantity:
TAR-T11041-100mg100mg£1,862.00
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This product comes from: United States.
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Further Information

Bioactivity:
Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs). Dihydro-β-carotene hydrobromide showed selectivity to α4β4 and α4β2nAChR, with IC50 of 0.19 and 0.37 μM, respectively.
CAS:
29734-68-7
Formula:
C16H22BrNO3
Molecular Weight:
356.26
Purity:
0.98
SMILES:
Br.CO[C@H]1CC=C2CCN3CCC4=C(CC(=O)OC4)[C@]23C1

References

1. Harvey SC, et al. Multiple determinants of dihydro-beta-erythroidine sensitivity on rat neuronal nicotinic receptor alpha subunits. J Neurochem. 1996 Nov;67(5):1953-9. 2. Tabbara RI, et al. Nicotine enhances responding for conditioned reinforcement via ?4?2 nicotinic acetylcholine receptors in the ventral tegmental area, but not the nucleus accumbens or the prefrontal cortex. Neuropharmacology. 2019 Apr;148:68-76. 3. Clementson S, et al. Enantioselective Total Synthesis of (+)-Dihydro-?-erythroidine. J Am Chem Soc. 2019 Jun 5;141(22):8783-8786.