TargetMol

Cytarabine

Product Code:
 
TAR-T1272
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1272-25mg25mg£95.00
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TAR-T1272-50mg50mg£102.00
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TAR-T1272-100mg100mg£113.00
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TAR-T1272-1mL1 mL * 10 mM (in DMSO)£116.00
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TAR-T1272-200mg200mg£124.00
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TAR-T1272-500mg500mg£145.00
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TAR-T1272-1g1g£159.00
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Further Information

Bioactivity:
Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. Cytarabine is an antimetabolite analog of cytidine with a modified sugar moiety (arabinose instead of ribose). This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair.
CAS:
147-94-4
Formula:
C9H13N3O5
Molecular Weight:
243.219
Pathway:
Metabolism; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Autophagy; Apoptosis; Microbiology/Virology
Purity:
0.9993
SMILES:
Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1
Target:
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite; Autophagy; HSV

References

1. Tobias SC, et al. Mol Pharm, 2004, 1(2), 112-116. 2. Veuger MJ, et al. Blood, 2002, 99(4), 1373-1380. 3. Besirli CG, et al. Cell Death Differ, 2003, 10(9), 1045-1058. 4. Richel DJ, Br J Cancer, 1988, 58(6), 730-733. 5. Yamauchi H, et al. Biol Reprod, 2004, 70(6), 1762-1767. 6. Shepshelovich D, et al. Pharmacodynamics of cytarabine induced leucopenia: a retrospective cohort study. Br J Clin Pharmacol. 2015 Apr;79(4):685-91. 7. Thieulent C, Hue E, Sutton G, et al. Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: efficacy of decitabine and valganciclovir alone or in combination[J]. Antiviral Research. 2020: 104931