TargetMol

GR 113808

Product Code:
 
TAR-T15414
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
GR 113808 displays 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. GR 113808 is a potent and highly selective antagonist of 5-HT4 receptor (pKb= 8.8).
CAS:
144625-51-4
Formula:
C19H27N3O4S
Molecular Weight:
393.5
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.98
SMILES:
Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Target:
5-HT Receptor

References

1. Gale JD, et al. GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor.Br J Pharmacol. 1994 Jan;111(1):332-8. 2. Spohn SN, et al.Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon.Gastroenterology. 2016 Nov;151(5):933-944.e3.