TargetMol

K777

Product Code:
 
TAR-T15641
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15641-1mg1mg£159.00
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TAR-T15641-5mg5mg£276.00
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TAR-T15641-1mL1 mL * 10 mM (in DMSO)£326.00
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TAR-T15641-10mg10mg£372.00
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TAR-T15641-25mg25mg£576.00
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TAR-T15641-50mg50mg£792.00
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TAR-T15641-100mg100mg£1,058.00
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TAR-T15641-500mg500mg£2,046.00
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Further Information

Bioactivity:
K777 is an orally active and irreversible inhibitor of cysteine protease with an IC50 of 60 nM for CYP3A4. K777 is a CCR4 antagonist and inhibits chemotaxis.
CAS:
233277-99-1
Formula:
C32H38N4O4S
Molecular Weight:
574.73
Pathway:
Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome; Metabolism
Purity:
0.9735
SMILES:
[C@H](CC1=CC=CC=C1)(C(N[C@@H](CCC2=CC=CC=C2)C=CS(=O)(=O)C3=CC=CC=C3)=O)NC(=O)N4CCN(C)CC4
Target:
P45; Cysteine Protease; CCR

References

Sato T, et al. Internalization of CCR4 and inhibition of chemotaxis by K777, a potent and selective CCR4 antagonist. Pharmacology. 2013;91(5-6):305-13. Ndao M, et al. A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection. Antimicrob Agents Chemother. 2013 Dec;57(12):6063-73. Zhou Y, et al. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Res. 2015 Apr;116:76-84. Jacobsen W, et al. In vitro evaluation of the disposition of A novel cysteine protease inhibitor. Drug Metab Dispos. 2000 Nov;28(11):1343-51.