TargetMol

Lesogaberan

Product Code:
 
TAR-T15737
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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CodeSizePrice
TAR-T15737-5mg5mg£850.00
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TAR-T15737-50mg50mg£1,661.00
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Quantity:
TAR-T15737-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Lesogaberan is an effective and selective GABAB receptor agonist (EC50: 8.6 nM for human recombinant GABAB receptors). For rat brain GABAB and GABAA receptors, the binding affinity (Kis) is 5.1 nM and 1.4 μM, respectively.
CAS:
344413-67-8
Formula:
C3H9FNO2P
Molecular Weight:
141.082
Pathway:
Membrane transporter/Ion channel; Neuroscience
Purity:
0.98
SMILES:
NC[C@@H](F)CP(O)=O
Target:
GABA Receptor

References

1. Lehmann A, et al. (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action. J Pharmacol Exp Ther. 2009 Nov;331(2):504-12. 2. Tian J, et al. Repurposing Lesogaberan to Promote Human Islet Cell Survival and ?-Cell Replication. J Diabetes Res. 2017;2017:6403539.