TargetMol

PF-04856264

Product Code:
 
TAR-T33943
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T33943-100mg100mgEnquire
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Further Information

Bioactivity:
PF-04856264 is a potent and selective human Nav1.7 voltage-gated sodium channel inhibitor (IC50 = 28 nM).
CAS:
1235397-05-3
Formula:
C20H15N5O3S2
Molecular Weight:
437.49
Purity:
0.98
SMILES:
Cn1nccc1-c1ccccc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1nccs1

References

McCormack K, Santos S, Chapman ML, Krafte DS, Marron BE, West CW, Krambis MJ, Antonio BM, Zellmer SG, Printzenhoff D, Padilla KM, Lin Z, Wagoner PK, Swain NA, Stupple PA, de Groot M, Butt RP, Castle NA. Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):E2724-32. doi: 10.1073/pnas.1220844110. Epub 2013 Jul 1. PubMed PMID: 23818614; PubMed Central PMCID: PMC3718154.