TargetMol

QD-394

Product Code:
 
TAR-T36514
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36514-5mg5mg£850.00
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Quantity:
TAR-T36514-50mg50mg£1,661.00
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Quantity:
TAR-T36514-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 μM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 μM, respectively). QD-394 acts synergistically with napabucasin to reduce colony formation in MIA PaCa-2 cells.
CAS:
2132411-21-1
Formula:
C19H19N5O2
Molecular Weight:
349.4
Purity:
0.98
SMILES:
O=C1C=C(C(C2=CN=CN=C12)=O)NC3=CC=C(N4CCN(CC4)C)C=C3

References

Hu, S., Sechi, M., Singh, P.K., et al.A novel redox modulator induces a GPX4-mediated cell death that is dependent on iron and reactive oxygen speciesJ. Med. Chem.63(17)9838-9855(2020)