TargetMol

O6-Benzylguanine

Product Code:
 
TAR-T7539
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7539-1mL1 mL * 10 mM (in DMSO)£95.00
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TAR-T7539-25mg25mg£104.00
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TAR-T7539-50mg50mg£120.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-T7539-100mg100mg£148.00
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This product comes from: United States.
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Further Information

Bioactivity:
O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
CAS:
19916-73-5
Formula:
C12H11N5O
Molecular Weight:
241.254
Pathway:
Apoptosis; DNA Damage/DNA Repair; Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
Nc1nc(OCc2ccccc2)c2nc[nH]c2n1
Target:
Apoptosis; DNA Alkylation; DNA/RNA Synthesis

References

Tacastacas J D , Chan D V , Carlson S . Evaluation of O6-Benzylguanine?Potentiated Topical Carmustine for Mycosis FungoidesA Phase 1-2 Clinical Trial[J]. JAMA Dermatology, 2017, 153(5):p?gs. 413-420. Dolan M E , Pegg A E . O6-Benzylguanine and its role in chemotherapy[J]. Clinical Cancer Research, 1997, 3(6):837-847.