TargetMol

UK-124114

Product Code:
 
TAR-T0124
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T0124-1mg1mg£113.00
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Quantity:
TAR-T0124-5mg5mg£165.00
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TAR-T0124-10mg10mg£211.00
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TAR-T0124-25mg25mg£303.00
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Quantity:
TAR-T0124-50mg50mg£417.00
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Quantity:
TAR-T0124-100mg100mg£584.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
UK-124114 is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, selamectin (0.1 μg/ml) shows the effect of growth inhibition.
CAS:
165108-07-6
Formula:
C43H63NO11
Molecular Weight:
769.96
Purity:
0.9944
SMILES:
C[C@@H](CC1)[C@@H](C2CCCCC2)O[C@]1(C[C@H](C1)OC([C@@H]([C@@]([C@@H]2OC3)(/C3=CC=C[C@@H]3C)O)C=C(C)/C2=NO)=O)O[C@@H]1C/C=C(C)/[C@H]3O[C@@H](C[C@@H]1OC)O[C@@H](C)[C@@H]1O

References

1. Holden-Dye, L. , et al. Anthelmintic drugs and nematicides: Studies in Caenorhabditis elegans. WormBook 16, (2014). 2. Michael, B.,et al. Comparison of ivermectin, doramectin, selamectin, and eleven intermediates in a nematode larval development assay. Journal of Parasitology 87(3), 692-696 (2001). 3. Sarasombath P T , Thammapalo S , Loymek S , et al. First study of topical selamectin efficacy for treating cats naturally infected with Brugia malayi and Brugia pahangi under field conditions[J]. Parasitology Research, 2019, 118(4):1289-1297.