TargetMol

GW274150 phosphate

Product Code:
 
TAR-T11518
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
GW274150 phosphate is a selective, orally active, and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50: 2.19 μM; Kd: 40 nM) and rat iNOS (ED50: 1.15 μM).
CAS:
438542-15-5
Formula:
C8H20N3O6PS
Molecular Weight:
317.3
Pathway:
Immunology/Inflammation
Purity:
0.98
SMILES:
OP(O)(O)=O.CC(=N)NCCSCC[C@H](N)C(O)=O
Target:
NOS

References

1. Alderton WK, et al. GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo.Br J Pharmacol. 2005 Jun;145(3):301-12. 2. Dugo L, et al. Effects of GW274150, a novel and selective inhibitor of iNOS activity, in acute lung inflammation. Br J Pharmacol. 2004 Mar;141(6):979-87. Epub 2004 Feb 3. Broom L, et al. Neuroprotection?by the?selective?iNOS?inhibitor?GW274150?in a?model?of?Parkinson?disease.Free Radic Biol Med.?2011 Mar 1;50(5):633-40.