TargetMol

Clonidine hydrochloride

Product Code:
 
TAR-T1247
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1247-50mg50mg£101.00
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TAR-T1247-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T1247-100mg100mg£114.00
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TAR-T1247-200mg200mg£124.00
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TAR-T1247-500mg500mg£185.00
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This product comes from: United States.
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Further Information

Bioactivity:
Clonidine is a centrally active alpha-adrenergic agonist used predominantly as an antihypertensive agent, usually in combination with other agents. Despite wide scale use for many years, clonidine has not been linked definitively to either serum aminotransferase elevations or clinically apparent liver injury.
CAS:
4205-91-8
Formula:
C9H10Cl3N3
Molecular Weight:
266.55
Pathway:
Neuroscience; GPCR/G Protein
Purity:
0.9999
SMILES:
Cl.Clc1cccc(Cl)c1NC1=NCCN1
Target:
Adrenergic Receptor

References

1. Bugajski J, et al. The involvement of central alpha-adrenergic and histamine H2-receptors in the hypothermia induced by clonidine in the rat. Neuropharmacology. 1980 Jan;19(1):9-15. 2. Zhang YM, et al. Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells. Peptides. 2009 Sep;30(9):1746-52. 3. Jentsch JD, et al. Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype. Brain Res. 2008 Dec 30;1246:41-6. 4. Nassar N, et al. Brainstem adenosine A1 receptor signaling masks phosphorylated extracellular signal-regulated kinase 1/2-dependent hypotensive action of clonidine in conscious normotensive rats. J Pharmacol Exp Ther. 2009 Jan;328(1):83-9. 5. Himmel H M, Faelker T M E. Pupillary function test in rat: Establishment of imaging setup and pharmacological validation within modified Irwin test. Journal of pharmacological and toxicological methods. 2019: 106588.