TargetMol

(Rac)-PT2399

Product Code:
 
TAR-T12675
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12675-5mg5mg£304.00
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TAR-T12675-50mg50mg£1,163.00
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TAR-T12675-100mg100mg£1,830.00
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This product comes from: United States.
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Further Information

Bioactivity:
(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).
CAS:
1672662-07-5
Formula:
C17H10F5NO4S
Molecular Weight:
419.32
Pathway:
Angiogenesis; Chromatin/Epigenetic
Purity:
0.98
SMILES:
OC1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)C(F)F
Target:
HIF

References

1. Wehn PM, et al. Design and Activity of Specific Hypoxia-Inducible Factor-2? (HIF-2?) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385). J Med Chem. 2018 Nov 8;61(21):9691-9721.