TargetMol

ABL127

Product Code:
 
TAR-T14084
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14084-50mg50mg£645.00
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Quantity:
TAR-T14084-100mg100mg£870.00
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This product comes from: United States.
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Further Information

Bioactivity:
ABL127 is a selective and covalent inhibitor of protein methylesterase 1 (PME-1). In HEK293T and MDA-MB-231 cells, the IC50s values are 6.4 nM and 4.2 nM , respectively.
CAS:
1073529-41-5
Formula:
C17H20N2O5
Molecular Weight:
332.356
Purity:
0.98
SMILES:
COC(=O)N1N(C(=O)OC)[C@@](C2CCCC2)(C1=O)c1ccccc1

References

1. Pusey M, et al. Inhibition of protein methylesterase 1 decreased cancerous phenotypes in endometrial adenocarcinoma cell lines and xenograft tumor models. Tumour Biol. 2016 Sep;37(9):11835-11842. 2. Bachovchin DA, et al. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6811-6.