TargetMol

Atabecestat

Product Code:
 
TAR-T14338
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14338-5mg5mg£371.00
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TAR-T14338-50mg50mg£1,564.00
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TAR-T14338-100mg100mg£2,392.00
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This product comes from: United States.
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Further Information

Bioactivity:
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction and it is tolerated and displays a sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1].
CAS:
1200493-78-2
Formula:
C18H14FN5OS
Molecular Weight:
367.4
Pathway:
Neuroscience
Purity:
0.98
SMILES:
C[C@]1(C=CSC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Target:
BACE

References

1. Timmers M, et al. Profiling the dynamics of CSF and plasma A? reduction after treatment with JNJ-54861911, a?potent?oral BACE inhibitor.Alzheimers Dement (N Y).?2016 Aug 24;2(3):202-212.