TargetMol

JNJ-46281222

Product Code:
 
TAR-T15618
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15618-5mg5mg£371.00
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Quantity:
TAR-T15618-50mg50mg£1,564.00
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Quantity:
TAR-T15618-100mg100mg£2,633.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71).
CAS:
1254980-38-5
Formula:
C23H25F3N4
Molecular Weight:
414.476
Pathway:
Neuroscience
Purity:
0.98
SMILES:
FC(F)(F)c1c(CN2CCC(CC2)c2ccccc2)ccn2c(CC3CC3)nnc12
Target:
GluR

References

1. Doornbos ML,et al. Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.Br J Pharmacol. 2016 Feb;173(3):588-600.