TargetMol

KHK-IN-1 hydrochloride

Product Code:
 
TAR-T15659
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15659-5mg5mg£351.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T15659-50mg50mg£1,508.00
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Quantity:
TAR-T15659-100mg100mg£2,247.00
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This product comes from: United States.
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Further Information

Bioactivity:
KHK-IN-1 hydrochloride is a potent inhibitor of ketohexokinase (KHK) (IC50: 12 nM). In the ATP-binding region of KHK, KHK-IN-1 hydrochloride interacts with Asp-27B.
CAS:
1303470-48-5
Formula:
C21H27ClN8S
Molecular Weight:
459.01
Purity:
0.98
SMILES:
Cl.CSc1ccccc1Nc1nc(nc2c(NCC3CC3)ncnc12)N1CCNCC1

References

1. Maryanoff BE, et al. Pyrimidinopyrimidine inhibitors of ketohexokinase: exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5326-9. 2. Maryanoff BE, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43.