TargetMol

PD 144418

Product Code:
 
TAR-T16445
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16445-5mg5mg£267.00
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TAR-T16445-50mg50mg£838.00
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TAR-T16445-100mg100mg£1,227.00
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Further Information

Bioactivity:
PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for σ1 and σ2 respectively). It shows devoid of any significant affinity for other receptors, ion channels, and enzymes.
CAS:
154130-99-1
Formula:
C18H22N2O
Molecular Weight:
282.387
Pathway:
GPCR/G Protein
Purity:
0.98
SMILES:
CCCN1CCC=C(C1)c1cc(no1)-c1ccc(C)cc1
Target:
Sigma receptor

References

1. Akunne HC, et al. The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology. 1997 Jan;36(1):51-62. 2. Lever JR, et al. Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418. J Pharmacol Exp Ther. 2014 Oct;351(1):153-63.