TargetMol

PF-06372865

Product Code:
 
TAR-T16489
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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Further Information

Bioactivity:
PF-06372865 is a high-affinity ligand at GABAA receptors containing α1/α2/α3/α5 subunits (Kis: 2.9 nM, 21 nM, 134 nM for α2, α1 PAM, α2 PAM, respectively). It also has a low affinity for α4/α6 subunits. PF-06372865 is an orally active and α2/α3/α5 subtype-selective GABAA positive allosteric modulator. PF-06372865 has the potential for epilepsy.
CAS:
1614245-70-3
Formula:
C22H21FN4O3S
Molecular Weight:
440.49
Purity:
0.98
SMILES:
CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1OC)S(=O)(=O)CC

References

1. Owen RM, et al. Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865). J Med Chem. 2019 Jun 27;62(12):5773-5796.